Nucleic Acid Polymer Therapy for Hepatitis B Virus: Strong Hepatitis B Surface Antigen Decline But Many Unanswered Questions
نویسندگان
چکیده
We read with great interest the article by Bazinet et al, which describes their findings from a phase II study of combination therapy tenofovir, peginterferon-alfa (pegIFN), and nucleic acid polymers (NAPs) REP-2139 or 2165 in hepatitis B e antigen–negative chronic B.1 The addition either NAP induced strong surface antigen (HBsAg) declines, resulting HBsAg undetectability ?50% patients. A significant proportion responses were sustained off therapy, negativity 42% at 24–48 weeks after treatment.
منابع مشابه
A cellular protein which binds hepatitis B virus but not hepatitis B surface antigen.
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2021
ISSN: ['1528-0012', '0016-5085']
DOI: https://doi.org/10.1053/j.gastro.2020.06.097